CALB2

mutation — cross-omics
Cross-omicsMUTATION → RNACell-linePairwise association · TCGA cohorts

Across TCGA cell cohorts, CALB2 mutation is significantly associated with the RNA expression of many other genes, with 2 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CALB2-associated genes across cancer lineages are ACER1 and PRAMEF20. Each is linked with CALB2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CALB2-to-partner and partner-to-CALB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACER1 grouped by CALB2-low versus CALB2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CALB2→partner) and Y-score (partner→CALB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
LARGE_INTESTINEACER1 →+0.094+3.823.002.00631
LARGE_INTESTINEPRAMEF20 →+0.012+4.437<.001.00431
Each partner links to its Q-omics profile. Showing the 2 strongest of 2 associations by consensus.

ACER1 by CALB2 expression — LARGE_INTESTINE

Box plot of ACER1 in CALB2-low vs CALB2-high samples in LARGE_INTESTINE.

Explore this box plot interactively →

Exploration