CADM4

Across TCGA patient cohorts, CADM4 mutation is significantly associated with the RNA expression of many other genes, with 674 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CADM4-associated genes across cancer lineages are RNU4-58P, LINC02441, and MIR4285. Each is linked with CADM4 in more than 2 cancer types. Because this analysis shows association rather than direction, both CADM4-to-partner and partner-to-CADM4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU4-58P grouped by CADM4-low versus CADM4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CADM4→partner) and Y-score (partner→CADM4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNU4-58P →	+0.198	+2.674	.004	.006	3	3
BRCA	LINC02441 →	+0.141	+6.382	<.001	.001	3	2
SKCM	MIR4285 →	+0.612	+3.111	<.001	.001	3	2
CESC	SPECC1P2 →	+0.185	+6.342	<.001	.001	3	2
CESC	SIGLEC24P →	+0.051	+6.144	<.001	.001	3	2
HNSC	IFNNP1 →	+0.087	+6.468	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 674 associations by consensus.

RNU4-58P by CADM4 expression — UCEC

Explore this box plot interactively →