CACTIN

Across TCGA patient cohorts, CACTIN protein abundance is significantly associated with the RNA expression of many other genes, with 14,415 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible CACTIN-associated genes across cancer lineages are TGOLN2, OIP5, and FBL. Each is linked with CACTIN in more than 3 cancer types. Because this analysis shows association rather than direction, both CACTIN-to-partner and partner-to-CACTIN results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CACTIN versus TGOLN2 in OV, with a Pearson correlation of -0.33.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CACTIN→partner) and Y-score (partner→CACTIN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	TGOLN2 →	-0.637	-0.170	.006	.008	3	4
HNSC	OIP5 →	+0.634	+0.167	<.001	.005	3	4
BRCA	FBL →	+0.907	+0.307	<.001	<.001	3	4
HNSC	ARMC6 →	+0.686	+0.204	.004	<.001	3	4
BRCA	LSM7 →	+0.700	+0.243	<.001	<.001	3	4
BRCA	WDR74 →	+0.618	+0.227	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,415 associations by consensus.

CACTIN vs TGOLN2 — OV

Explore this scatter interactively →