CACTIN

Across TCGA pan-cancer cohorts, CACTIN RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of CACTIN’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where CACTIN RNA is more highly expressed in tumor relative to normal tissue. In most cancer types CACTIN is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.

HNSC, COAD, and LIHC are the cancer types where CACTIN tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CACTIN RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	III,IV	+0.991	<.001	12	view →
COAD	Female	All	+0.714	<.001	10	view →
LIHC	Female	II,III,IV	+0.994	<.001	9	view →
KIRP	All	II,III,IV	+0.508	.004	9	view →
KIRC	All	All	+0.341	<.001	9	view →
STAD	Male	II,III,IV	+0.985	<.001	8	view →
CHOL	Male	All	+1.690	<.001	5	view →
LUSC	All	II,III,IV	+0.603	<.001	5	view →
ESCA	All	II,III,IV	+0.414	.001	4	view →
THCA	Male	II,III,IV	−0.330	.003	4	view →
BLCA	All	All	+0.473	.005	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

CACTIN–HNSC

Open the HNSC breakdown →