CACTIN

Across TCGA cell cohorts, CACTIN mutation is significantly associated with the RNA expression of many other genes, with 172 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CACTIN-associated genes across cancer lineages are FAM149A, C12orf65, and CCR8. Each is linked with CACTIN in more than 1 cancer types. Because this analysis shows association rather than direction, both CACTIN-to-partner and partner-to-CACTIN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FAM149A grouped by CACTIN-low versus CACTIN-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CACTIN→partner) and Y-score (partner→CACTIN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	FAM149A →	+1.574	+3.502	<.001	.001	3	2
LARGE_INTESTINE	C12orf65 →	+0.462	+3.064	.002	.009	3	2
SOFT_TISSUE	CCR8 →	+0.022	+5.369	<.001	.004	3	1
SOFT_TISSUE	BHLHA9 →	+0.036	+5.977	<.001	.001	3	1
SOFT_TISSUE	GOLGA6L6 →	+0.013	+5.369	<.001	.004	3	1
BLOOD_Lymphoma	PRRG3 →	+0.275	+3.342	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 172 associations by consensus.

FAM149A by CACTIN expression — LARGE_INTESTINE

Explore this box plot interactively →