CACNG3

Across TCGA patient cohorts, CACNG3 mutation is significantly associated with the total protein of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CACNG3-associated genes across cancer lineages are MEK1, PCNA, and STAT3_pY705. Each is linked with CACNG3 in more than 1 cancer types. Because this analysis shows association rather than direction, both CACNG3-to-partner and partner-to-CACNG3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by CACNG3-low versus CACNG3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CACNG3→partner) and Y-score (partner→CACNG3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.319	+2.169	.020	.003	3	2
UCEC	PCNA →	+0.238	+2.169	.003	.003	3	2
UCEC	STAT3_pY705 →	-0.340	-1.807	<.001	.024	3	2
UCEC	ATM →	-0.419	-1.415	.013	.046	3	2
UCEC	4E-BP1 →	+0.270	+2.169	.007	.003	3	2
SKCM	MYH11 →	-0.594	-1.584	.039	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

MEK1 by CACNG3 expression — UCEC

Explore this box plot interactively →