CACNG3

Across TCGA pan-cancer cohorts, CACNG3 RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of CACNG3’s most consistent transcriptional readouts.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where CACNG3 RNA is repressed in tumor relative to normal tissue. In most cancer types CACNG3 is over-expressed in tumor, although a few such as LIHC and PAAD show the opposite, repressed pattern.

LIHC, LUAD, and HNSC are the cancer types where CACNG3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CACNG3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LIHC	Male	II,III,IV	−0.012	<.001	4	view →
LUAD	All	All	+0.035	.027	3	view →
HNSC	Male	All	+0.012	.028	3	view →
PAAD	All	All	−0.197	.009	2	view →
STAD	All	All	+0.028	.037	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

CACNG3–LIHC

Open the LIHC breakdown →