CACNG3

Across TCGA pan-cancer cohorts, CACNG3 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated CACNG3 data layer compared with 10 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in ovarian serous cystadenocarcinoma (OV), where higher CACNG3 RNA is associated with better overall survival. In most high-consensus cancer types, elevated CACNG3 expression acts as an unfavorable survival marker, although some lineages such as OV and BLCA show a favorable association.

OV, BLCA, and HNSC are the cancer types where CACNG3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
OV	OS	Tertile	All	0.911	0.814	.016	48	view →
BLCA	OS	Tertile	III,IV	0.610	0.345	.004	46	view →
HNSC	OS	Quartile	All	0.502	0.321	.006	42	view →
KIRP	DFS	Quartile	II,III,IV	0.131	0.758	.001	41	view →
KICH	DFS	Tertile	II,III,IV	0.364	0.910	<.001	36	view →
CESC	DFS	Tertile	III,IV	0.792	0.269	.023	30	view →
COAD	OS	Tertile	IV	0.130	0.674	<.001	27	view →
SKCM	OS	Tertile	III,IV	0.947	0.758	.010	27	view →
LGG	DFS	Quartile	All	0.903	0.740	.001	22	view →
CHOL	OS	Tertile	IV	0.024	0.732	.014	18	view →
UVM	OS	Quartile	All	0.675	0.963	.005	18	view →
ACC	DFS	Tertile	III,IV	0.046	0.670	.001	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

CACNG3–OV (OS)

Open the OV breakdown →