CACNA2D4

Across TCGA patient cohorts, CACNA2D4 mutation is significantly associated with the RNA expression of many other genes, with 4,705 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CACNA2D4-associated genes across cancer lineages are RCC1, NCAPH, and STIL. Each is linked with CACNA2D4 in more than 4 cancer types. Because this analysis shows association rather than direction, both CACNA2D4-to-partner and partner-to-CACNA2D4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RCC1 grouped by CACNA2D4-low versus CACNA2D4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CACNA2D4→partner) and Y-score (partner→CACNA2D4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RCC1 →	+0.307	+2.258	.006	<.001	3	5
COAD	NCAPH →	+0.450	+3.472	.003	.002	3	5
COAD	STIL →	+0.560	+4.013	<.001	<.001	3	5
UCEC	CHAF1A →	+0.647	+2.606	<.001	<.001	3	5
LUAD	PLK1 →	+0.802	+3.345	.004	.005	3	4
LUAD	CDK1 →	+0.812	+3.477	.006	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,705 associations by consensus.

RCC1 by CACNA2D4 expression — UCEC

Explore this box plot interactively →