CACNA2D4

Across TCGA pan-cancer cohorts, CACNA2D4 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated CACNA2D4 data layer compared with 6 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher CACNA2D4 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated CACNA2D4 expression acts as an unfavorable survival marker, although some lineages such as HNSC and UCEC show a favorable association.

HNSC, OV, and UCEC are the cancer types where CACNA2D4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.781	0.637	<.001	123	view →
OV	OS	Tertile	III,IV	0.248	0.375	<.001	54	view →
UCEC	DFS	Tertile	III,IV	0.890	0.744	.009	52	view →
SKCM	OS	Median	All	0.416	0.265	<.001	50	view →
CESC	DFS	Tertile	II,III,IV	0.647	0.327	.001	38	view →
LGG	OS	Quartile	All	0.392	0.633	<.001	36	view →
UVM	DFS	Tertile	II,III,IV	0.441	0.739	.004	32	view →
DLBC	DFS	Quartile	All	0.345	1.000	.018	19	view →
CHOL	DFS	Median	All	0.680	0.190	.010	16	view →
LUAD	OS	Quartile	III,IV	0.804	0.402	.007	15	view →
KIRP	DFS	Median	All	0.978	0.798	.009	14	view →
GBM	DFS	Tertile	All	0.182	0.289	.004	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

CACNA2D4–HNSC (DFS)

Open the HNSC breakdown →