CACNA1S

Across TCGA cell cohorts, CACNA1S mutation is significantly associated with the RNA expression of many other genes, with 688 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CACNA1S-associated genes across cancer lineages are CBLIF, RNF148, and DEFB4B. Each is linked with CACNA1S in more than 1 cancer types. Because this analysis shows association rather than direction, both CACNA1S-to-partner and partner-to-CACNA1S results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CBLIF grouped by CACNA1S-low versus CACNA1S-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CACNA1S→partner) and Y-score (partner→CACNA1S) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	CBLIF →	+0.095	+4.192	<.001	.003	3	2
BLOOD_Lymphoma	RNF148 →	+0.332	+3.736	.009	.009	3	2
SOFT_TISSUE	DEFB4B →	+0.072	+4.392	<.001	.004	3	2
SOFT_TISSUE	OR52E5 →	+0.020	+4.392	<.001	.004	3	2
URINARY_TRACT	OR3A3 →	+0.008	+3.459	<.001	.002	3	2
SKIN	PSD4 →	+1.085	+2.451	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 688 associations by consensus.

CBLIF by CACNA1S expression — BLOOD_Lymphoma

Explore this box plot interactively →