CACNA1S

Across TCGA pan-cancer cohorts, CACNA1S RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated CACNA1S data layer compared with 10 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher CACNA1S RNA is associated with worse overall survival. In most high-consensus cancer types, elevated CACNA1S expression acts as an unfavorable survival marker, although some lineages such as KIRC and SCLC show a favorable association.

KIRP, KIRC, and HNSC are the cancer types where CACNA1S RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Median	All	0.470	0.799	<.001	75	view →
KIRC	DFS	Quartile	III,IV	0.699	0.495	.003	61	view →
HNSC	OS	Median	III,IV	0.669	0.782	.002	44	view →
SCLC	DFS	Quartile	III,IV	0.645	0.119	<.001	41	view →
BRCA	OS	Median	All	0.891	0.945	<.001	38	view →
UVM	DFS	Quartile	All	0.368	0.737	.003	31	view →
MESO	OS	Tertile	All	0.200	0.624	.015	24	view →
LUAD	DFS	Median	IV	0.408	0.748	.025	24	view →
ACC	DFS	Quartile	II,III,IV	0.182	0.628	.031	24	view →
DLBC	DFS	Quartile	All	0.628	1.000	.009	20	view →
LAML	DFS	Tertile	All	0.561	0.277	.022	12	view →
CHOL	DFS	Median	All	0.627	0.264	.017	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

CACNA1S–KIRP (OS)

Open the KIRP breakdown →