CACNA1S

Across TCGA pan-cancer cohorts, CACNA1S RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of CACNA1S’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where CACNA1S RNA is repressed in tumor relative to normal tissue. In most cancer types CACNA1S is over-expressed in tumor, although a few such as KIRP and HNSC show the opposite, repressed pattern.

KIRP, HNSC, and LUAD are the cancer types where CACNA1S tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CACNA1S RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	Male	II,III,IV	−0.664	<.001	11	view →
HNSC	Male	All	−1.773	.005	8	view →
LUAD	Female	III,IV	−0.810	<.001	8	view →
LIHC	All	II,III,IV	+0.076	<.001	8	view →
LUSC	Female	All	−0.640	<.001	6	view →
KIRC	Male	All	−0.370	<.001	6	view →
BLCA	Male	IV	−0.030	.032	3	view →
KICH	All	All	−0.227	.019	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

CACNA1S–KIRP

Open the KIRP breakdown →