CACNA1S

Across TCGA cell cohorts, CACNA1S mutation is significantly associated with the mutation status of many other genes, with 5,211 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CACNA1S-associated genes across cancer lineages are COL11A1, SCN2A, and SPEG. Each is linked with CACNA1S in more than 5 cancer types. Because this analysis shows association rather than direction, both CACNA1S-to-partner and partner-to-CACNA1S results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, COL11A1 grouped by CACNA1S-low versus CACNA1S-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CACNA1S→partner) and Y-score (partner→CACNA1S) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	COL11A1 →	+2.655	+2.784	.007	.007	1	6
SOFT_TISSUE	SCN2A →	+3.977	+3.437	<.001	<.001	1	6
BLOOD_Leukemia	SPEG →	+2.399	+2.962	.002	.002	1	6
LARGE_INTESTINE	DCC →	+2.754	+2.182	<.001	<.001	1	6
SOFT_TISSUE	DSP →	+3.562	+2.985	.008	.008	1	6
BONE	PAPPA2 →	+4.437	+5.000	.007	.007	1	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,211 associations by consensus.

COL11A1 by CACNA1S expression — SOFT_TISSUE

Explore this box plot interactively →