CACNA1I

Across TCGA patient cohorts, CACNA1I mutation is significantly associated with the RNA expression of many other genes, with 6,876 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CACNA1I-associated genes across cancer lineages are AURKB, CEP78, and CHCHD4. Each is linked with CACNA1I in more than 5 cancer types. Because this analysis shows association rather than direction, both CACNA1I-to-partner and partner-to-CACNA1I results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AURKB grouped by CACNA1I-low versus CACNA1I-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CACNA1I→partner) and Y-score (partner→CACNA1I) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	AURKB →	+0.610	+3.727	<.001	<.001	3	6
UCEC	CEP78 →	+0.470	+1.624	<.001	<.001	3	5
STAD	CHCHD4 →	+0.460	+3.346	.002	.004	3	5
UCEC	ZNF367 →	+0.660	+1.963	<.001	<.001	3	5
UCEC	SAAL1 →	+0.452	+1.809	<.001	<.001	3	5
UCEC	EXO1 →	+0.670	+1.501	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,876 associations by consensus.

AURKB by CACNA1I expression — COAD

Explore this box plot interactively →