CACNA1I

Across TCGA pan-cancer cohorts, CACNA1I RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of CACNA1I’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where CACNA1I RNA is repressed in tumor relative to normal tissue. In most cancer types CACNA1I is over-expressed in tumor, although a few such as THCA and COAD show the opposite, repressed pattern.

THCA, LUAD, and KICH are the cancer types where CACNA1I tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CACNA1I RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Female	All	−1.047	<.001	7	view →
LUAD	Female	All	+0.392	<.001	6	view →
KICH	All	All	+0.443	.006	4	view →
BRCA	Female	II,III,IV	+0.290	<.001	4	view →
KIRC	Male	All	+0.045	<.001	4	view →
UCEC	All	All	+0.436	.016	2	view →
LUSC	All	All	+0.320	.004	2	view →
LIHC	All	All	+0.250	.014	2	view →
COAD	Female	All	−0.146	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

CACNA1I–THCA

Open the THCA breakdown →