CACNA1I

Across TCGA pan-cancer cohorts, CACNA1I RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated CACNA1I data layer compared with 11 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher CACNA1I RNA is associated with better overall survival. In most high-consensus cancer types, elevated CACNA1I expression acts as an unfavorable survival marker, although some lineages such as SKCM and BLCA show a favorable association.

SKCM, BLCA, and OV are the cancer types where CACNA1I RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	OS	Median	All	0.409	0.277	<.001	59	view →
BLCA	OS	Tertile	All	0.516	0.348	.008	51	view →
OV	OS	Quartile	All	0.323	0.451	.005	50	view →
UVM	DFS	Quartile	II,III,IV	0.416	0.819	<.001	42	view →
STAD	DFS	Median	All	0.329	0.475	.005	40	view →
LGG	OS	Tertile	All	0.930	0.840	.001	33	view →
KIRP	OS	Tertile	II,III,IV	0.508	0.801	.009	31	view →
CESC	OS	Median	IV	0.597	0.090	.003	18	view →
UCS	DFS	Quartile	III,IV	0.550	0.175	.037	12	view →
LUAD	DFS	Quartile	All	0.583	0.238	.023	12	view →
SCLC	OS	Tertile	All	0.927	0.662	.009	12	view →
CHOL	DFS	Quartile	All	0.687	0.148	.009	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

CACNA1I–SKCM (OS)

Open the SKCM breakdown →