CACNA1I

Across TCGA patient cohorts, CACNA1I mutation is significantly associated with the total protein of many other genes, with 83 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CACNA1I-associated genes across cancer lineages are ASNS, 4E-BP1, and eIF4E. Each is linked with CACNA1I in more than 4 cancer types. Because this analysis shows association rather than direction, both CACNA1I-to-partner and partner-to-CACNA1I results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by CACNA1I-low versus CACNA1I-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CACNA1I→partner) and Y-score (partner→CACNA1I) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	ASNS →	+0.712	+2.584	<.001	.010	3	5
UCEC	4E-BP1 →	+0.330	+2.392	<.001	<.001	3	4
UCEC	eIF4E →	+0.200	+2.000	<.001	<.001	3	4
UCEC	ACC1 →	+0.338	+1.938	.001	.001	3	4
UCEC	GAPDH →	+0.334	+1.502	.028	.025	3	3
STAD	PCNA →	+0.332	+3.459	.005	.004	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 83 associations by consensus.

ASNS by CACNA1I expression — STAD

Explore this box plot interactively →