CACNA1I

Across TCGA cell cohorts, CACNA1I mutation is significantly associated with the RNA expression of many other genes, with 680 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CACNA1I-associated genes across cancer lineages are C1orf146, OR1L3, and ARMH2. Each is linked with CACNA1I in more than 1 cancer types. Because this analysis shows association rather than direction, both CACNA1I-to-partner and partner-to-CACNA1I results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C1orf146 grouped by CACNA1I-low versus CACNA1I-high in PANCREAS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CACNA1I→partner) and Y-score (partner→CACNA1I) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	C1orf146 →	+0.023	+5.614	<.001	.002	3	2
OVARY	OR1L3 →	+0.031	+2.859	<.001	.008	3	2
BLOOD_Lymphoma	ARMH2 →	+0.065	+2.440	.004	.009	3	2
BREAST	IQCA1L →	+0.070	+2.836	.001	.009	3	2
CNS	IFNK →	+0.115	+3.459	<.001	.006	3	2
LUNG_NSCLC_LUAD	DGKE →	-0.875	-3.475	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 680 associations by consensus.

C1orf146 by CACNA1I expression — PANCREAS

Explore this box plot interactively →