Across TCGA patient cohorts, CACNA1E mutation is significantly associated with the RNA expression of many other genes, with 9,158 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CACNA1E-associated genes across cancer lineages are MCM7, PAXIP1, and OTX1. Each is linked with CACNA1E in more than 6 cancer types. Because this analysis shows association rather than direction, both CACNA1E-to-partner and partner-to-CACNA1E results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CACNA1E→partner) and Y-score (partner→CACNA1E) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	MCM7 →	+0.429	+1.383	<.001	<.001	3	7
UCEC	PAXIP1 →	+0.257	+1.349	<.001	<.001	3	7
LUAD	OTX1 →	+0.446	+1.766	<.001	<.001	3	6
UCEC	CACYBP →	+0.376	+1.218	<.001	<.001	3	6
CESC	TCF3 →	+0.595	+3.817	.001	<.001	3	6
READ	CLSPN →	+0.820	+3.340	<.001	.004	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,158 associations by consensus.

Exploration

CACNA1E survival (RNA) · tumor vs normal (RNA) · all CACNA1E data types