CACNA1C-IT3

Across TCGA patient cohorts, CACNA1C-IT3 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,311 significant associations in total. STAD shows the largest number of these associations.

The most reproducible CACNA1C-IT3-associated GO terms across cancer lineages are Vesicle localization, Regulation of receptor-mediated endocytosis, and Positive regulation of neurogenesis. Each is linked with CACNA1C-IT3 in more than 12 cancer types. Because this analysis shows association rather than direction, both CACNA1C-IT3-to-partner and partner-to-CACNA1C-IT3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Vesicle localization grouped by CACNA1C-IT3-low versus CACNA1C-IT3-high in ESCA.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CACNA1C-IT3→partner) and Y-score (partner→CACNA1C-IT3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ESCA	Vesicle localization →	+0.045	+0.123	<.001	<.001	3	13
STAD	Regulation of receptor-mediated endocytosis →	+0.041	+0.126	<.001	<.001	3	12
STAD	Positive regulation of neurogenesis →	+0.045	+0.185	<.001	<.001	3	12
STAD	Positive regulation of nervous system development →	+0.035	+0.166	<.001	<.001	3	12
STAD	tRNA threonylcarbamoyladenosine metabolic process →	+0.056	+0.132	<.001	<.001	3	12
STAD	Positive regulation of translation →	+0.056	+0.159	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,311 associations by consensus.

Vesicle localization by CACNA1C-IT3 expression — ESCA

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