CACNA1C-IT3

Across TCGA pan-cancer cohorts, CACNA1C-IT3 RNA is linked to patient survival in 14 of 34 cancer types, making it the most broadly survival-associated CACNA1C-IT3 data layer.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where higher CACNA1C-IT3 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated CACNA1C-IT3 expression acts as an unfavorable survival marker, although some lineages such as LAML and PAAD show a favorable association.

LIHC, SKCM, and BLCA are the cancer types where CACNA1C-IT3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LIHC	OS	Tertile	II,III,IV	0.223	0.648	<.001	99	view →
SKCM	OS	Tertile	III,IV	0.110	0.414	<.001	60	view →
BLCA	DFS	Tertile	IV	0.168	0.489	.003	54	view →
THCA	DFS	Tertile	II,III,IV	0.167	0.718	<.001	54	view →
LAML	DFS	Tertile	All	0.706	0.462	<.001	50	view →
LUAD	OS	Tertile	III,IV	0.542	0.679	.023	30	view →
ACC	OS	Tertile	All	0.561	0.829	.009	30	view →
PAAD	OS	Tertile	All	0.638	0.328	.008	21	view →
STAD	OS	Quartile	IV	0.624	0.215	.015	19	view →
CHOL	OS	Tertile	All	0.154	0.793	.004	18	view →
MESO	DFS	Tertile	IV	0.130	0.405	.019	18	view →
READ	DFS	Tertile	IV	0.255	0.628	.020	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 14 lineages.

CACNA1C-IT3–LIHC (OS)

Open the LIHC breakdown →