CACNA1C-IT2

Across TCGA pan-cancer cohorts, CACNA1C-IT2 RNA is linked to patient survival in 15 of 34 cancer types, making it the most broadly survival-associated CACNA1C-IT2 data layer.

The strongest signal is observed in breast invasive carcinoma (BRCA), where higher CACNA1C-IT2 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated CACNA1C-IT2 expression acts as an unfavorable survival marker, although some lineages such as CHOL and LUAD show a favorable association.

BRCA, ACC, and READ are the cancer types where CACNA1C-IT2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BRCA	DFS	Median	II,III,IV	0.844	0.914	<.001	76	view →
ACC	DFS	Tertile	All	0.367	0.732	.001	44	view →
READ	DFS	Tertile	IV	0.027	0.636	<.001	36	view →
CHOL	OS	Quartile	All	0.942	0.490	.010	32	view →
LUAD	OS	Tertile	III,IV	0.681	0.460	.026	30	view →
SKCM	DFS	Tertile	II,III,IV	0.108	0.246	.002	24	view →
HNSC	DFS	Tertile	II,III,IV	0.454	0.686	.022	21	view →
KIRP	DFS	Tertile	All	0.765	0.888	.021	18	view →
STAD	DFS	Quartile	All	0.456	0.565	.013	14	view →
MESO	DFS	Tertile	III,IV	0.299	0.494	.019	12	view →
THYM	DFS	Tertile	All	0.975	0.840	.015	10	view →
LGG	DFS	Median	All	0.557	0.357	.008	5	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 15 lineages.

CACNA1C-IT2–BRCA (DFS)

Open the BRCA breakdown →