CACNA1C-IT2

Across TCGA pan-cancer cohorts, CACNA1C-IT2 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of CACNA1C-IT2’s most consistent transcriptional readouts.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where CACNA1C-IT2 RNA is repressed in tumor relative to normal tissue. In most cancer types CACNA1C-IT2 is over-expressed in tumor, although a few such as UCEC and BLCA show the opposite, repressed pattern.

UCEC, BLCA, and THCA are the cancer types where CACNA1C-IT2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CACNA1C-IT2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
UCEC	All	All	−0.508	<.001	6	view →
BLCA	All	III,IV	−0.397	.014	6	view →
THCA	All	All	+0.049	<.001	4	view →
HNSC	All	III,IV	+0.040	.006	4	view →
READ	All	All	−0.186	.017	2	view →
PRAD	All	All	−0.099	.008	2	view →
LUSC	Male	All	−0.072	.032	2	view →
BRCA	Female	All	−0.057	.012	2	view →
STAD	All	All	−0.132	.020	1	view →
KIRC	Male	IV	+0.104	.014	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

CACNA1C-IT2–UCEC

Open the UCEC breakdown →