CACNA1C-AS4

Across TCGA pan-cancer cohorts, CACNA1C-AS4 RNA is linked to patient survival in 14 of 34 cancer types, making it the most broadly survival-associated CACNA1C-AS4 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher CACNA1C-AS4 RNA is associated with better overall survival. In most high-consensus cancer types, elevated CACNA1C-AS4 expression acts as an unfavorable survival marker, although some lineages such as HNSC and LGG show a favorable association.

HNSC, TGCT, and ACC are the cancer types where CACNA1C-AS4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	IV	0.960	0.704	.007	75	view →
TGCT	DFS	Tertile	II,III,IV	0.622	0.978	.016	54	view →
ACC	DFS	Tertile	III,IV	0.300	0.731	<.001	54	view →
LGG	OS	Median	All	0.533	0.344	<.001	47	view →
UCEC	DFS	Tertile	IV	0.263	0.721	.011	36	view →
LAML	DFS	Quartile	All	0.713	0.498	.004	28	view →
LUSC	OS	Tertile	III,IV	0.054	0.768	<.001	24	view →
LIHC	DFS	Tertile	II,III,IV	0.130	0.427	.007	18	view →
PAAD	DFS	Tertile	All	0.438	0.232	.016	12	view →
SARC	OS	Tertile	All	0.324	0.564	.033	12	view →
PRAD	OS	Tertile	All	0.978	0.997	.003	12	view →
GBM	DFS	Tertile	All	0.163	0.317	.025	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 14 lineages.

CACNA1C-AS4–HNSC (OS)

Open the HNSC breakdown →