Q-omics provides the consensus-scored CACNA1C-AS4 profile across patient tissues and cancer cell-line models. CACNA1C-AS4 expression is associated with patient survival in 14 of 34 cancer types, with the highest sampling consensus in HNSC. Among the 18 cancer types available for tumor–normal comparison, CACNA1C-AS4 is differentially expressed in 2, with the highest sampling consensus in UCEC. Additionally, CACNA1C-AS4 RNA expression shows 16,765 significant protein co-abundance associations, with the highest sampling consensus in LSCC. Together, these results highlight HNSC, UCEC, and LSCC as cancer lineages where CACNA1C-AS4 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for CACNA1C-AS4 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes CACNA1C-AS4 survival associations across molecular data types. CACNA1C-AS4 RNA expression shows survival associations in the most cancer types (14). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible CACNA1C-AS4 RNA expression–survival associations across cancer types. High CACNA1C-AS4 expression shows unfavorable associations in ACC, TGCT and UCEC, but favorable associations in HNSC, LGG and LAML. The HNSC Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p = .007). Together, the overview and detailed table identify HNSC as the clearest survival context for CACNA1C-AS4 RNA expression.
This table summarizes CACNA1C-AS4 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 2. The strongest signals are observed in UCEC for RNA.
This table ranks reproducible tumor–normal expression differences for CACNA1C-AS4. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. CACNA1C-AS4 shows lower tumor expression in UCEC and LUSC. The UCEC box plot shows higher CACNA1C-AS4 RNA expression in normal versus tumor tissue (log2 FC = −0.083, t-test p = .012).
This table shows molecular features associated with CACNA1C-AS4 in patient tissues and cancer cell lines. In patient samples, CACNA1C-AS4 shows the broadest associations at the RNA and protein expression levels, with LSCC recurring as the lineage with the largest associated feature set.
