CABYR

Across TCGA patient cohorts, CABYR mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CABYR-associated genes across cancer lineages are c-Met_pY1235, 4E-BP1, and C-Raf. Each is linked with CABYR in more than 1 cancer types. Because this analysis shows association rather than direction, both CABYR-to-partner and partner-to-CABYR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, c-Met_pY1235 grouped by CABYR-low versus CABYR-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CABYR→partner) and Y-score (partner→CABYR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	c-Met_pY1235 →	+0.068	+2.321	.026	.006	3	2
UCEC	4E-BP1 →	+0.231	+2.351	.038	.018	3	2
UCEC	C-Raf →	+0.175	+2.321	.003	.006	3	2
UCEC	EGFR_pY1068 →	-0.215	-1.807	.037	.027	3	1
UCEC	FOXO3a_pS318_S321 →	-0.118	-2.105	.021	.017	3	1
UCEC	Ku80 →	+0.290	+3.013	.002	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

c-Met_pY1235 by CABYR expression — UCEC

Explore this box plot interactively →