CA9

Across TCGA cell cohorts, CA9 mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CA9-associated genes across cancer lineages are OR14K1, CENPVL3, and BRINP2. Each is linked with CA9 in more than 1 cancer types. Because this analysis shows association rather than direction, both CA9-to-partner and partner-to-CA9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR14K1 grouped by CA9-low versus CA9-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CA9→partner) and Y-score (partner→CA9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	OR14K1 →	+0.068	+4.022	<.001	.006	3	1
LARGE_INTESTINE	CENPVL3 →	+0.181	+4.242	<.001	.001	3	1
LARGE_INTESTINE	BRINP2 →	+0.442	+3.658	<.001	.005	1	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

OR14K1 by CA9 expression — LARGE_INTESTINE

Explore this box plot interactively →