CA9

Across TCGA pan-cancer cohorts, CA9 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated CA9 data layer compared with 5 for mutation status and 3 for mass-spec protein.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where higher CA9 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated CA9 expression acts as an unfavorable survival marker, although some lineages such as UVM and KIRC show a favorable association.

LIHC, BRCA, and UVM are the cancer types where CA9 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LIHC	OS	Median	All	0.587	0.779	<.001	81	view →
BRCA	OS	Tertile	III,IV	0.469	0.792	<.001	77	view →
UVM	OS	Median	All	0.845	0.558	.002	69	view →
LUAD	OS	Median	All	0.612	0.753	<.001	55	view →
KIRC	OS	Tertile	All	0.701	0.532	.004	52	view →
SKCM	OS	Tertile	All	0.817	0.910	<.001	42	view →
ACC	DFS	Median	IV	0.595	0.150	.001	33	view →
KIRP	OS	Quartile	All	0.699	0.910	.008	32	view →
UCS	OS	Median	IV	0.404	0.752	.013	30	view →
CESC	DFS	Quartile	All	0.419	0.644	.012	28	view →
THYM	DFS	Median	III,IV	0.382	1.000	.002	23	view →
SCLC	DFS	Tertile	III,IV	0.322	0.777	.001	19	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

CA9–LIHC (OS)

Open the LIHC breakdown →