C9orf50

Across TCGA patient cohorts, C9orf50 mutation is significantly associated with the RNA expression of many other genes, with 345 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C9orf50-associated genes across cancer lineages are RNU6-470P, RNU6-120P, and RNU2-19P. Each is linked with C9orf50 in more than 1 cancer types. Because this analysis shows association rather than direction, both C9orf50-to-partner and partner-to-C9orf50 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-470P grouped by C9orf50-low versus C9orf50-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C9orf50→partner) and Y-score (partner→C9orf50) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNU6-470P →	+0.165	+3.008	.008	.007	3	2
UCEC	RNU6-120P →	+0.142	+3.008	.009	.007	3	2
SKCM	RNU2-19P →	+0.273	+7.816	<.001	.008	3	2
COAD	RN7SL83P →	+0.698	+5.977	<.001	<.001	3	2
COAD	RNU7-53P →	+0.875	+5.136	<.001	.002	3	2
COAD	MIR3688-1 →	+0.668	+4.308	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 345 associations by consensus.

RNU6-470P by C9orf50 expression — UCEC

Explore this box plot interactively →