C9orf50

Across TCGA pan-cancer cohorts, C9orf50 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated C9orf50 data layer compared with 4 for mutation status.

The strongest signal is observed in uveal melanoma (UVM), where higher C9orf50 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated C9orf50 expression acts as an unfavorable survival marker, although some lineages such as DLBC and THCA show a favorable association.

UVM, ACC, and DLBC are the cancer types where C9orf50 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Median	All	0.406	0.760	<.001	138	view →
ACC	DFS	Median	All	0.208	0.692	<.001	115	view →
DLBC	DFS	Median	All	0.810	0.315	.002	18	view →
THCA	OS	Median	III,IV	1.000	0.324	.003	16	view →
CESC	DFS	Median	All	0.779	0.863	.009	14	view →
SCLC	DFS	Tertile	III,IV	0.758	0.322	.007	12	view →
LAML	DFS	Tertile	All	0.507	0.692	.029	12	view →
LUAD	DFS	Tertile	IV	0.308	0.896	.013	12	view →
OV	DFS	Median	IV	0.226	0.393	.015	12	view →
LIHC	DFS	Tertile	All	0.250	0.488	.004	9	view →
THYM	DFS	Tertile	All	0.935	0.766	.012	9	view →
LUSC	DFS	Median	II,III,IV	0.235	0.456	.011	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

C9orf50–UVM (DFS)

Open the UVM breakdown →