C9orf24

Across TCGA patient cohorts, C9orf24 mutation is significantly associated with the RNA expression of many other genes, with 82 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C9orf24-associated genes across cancer lineages are RNU6-42P, RNA5SP419, and LINC02420. Each is linked with C9orf24 in more than 1 cancer types. Because this analysis shows association rather than direction, both C9orf24-to-partner and partner-to-C9orf24 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-42P grouped by C9orf24-low versus C9orf24-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C9orf24→partner) and Y-score (partner→C9orf24) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNU6-42P →	+0.870	+3.741	.001	.004	3	2
UCEC	RNA5SP419 →	+0.943	+2.755	<.001	.009	3	2
SKCM	LINC02420 →	+0.050	+4.402	<.001	.002	3	2
LIHC	MIR7845 →	+0.491	+5.268	<.001	.006	3	1
LIHC	OR7E4P →	+0.104	+5.108	.002	.008	3	1
BLCA	OR6J1 →	+0.044	+4.788	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 82 associations by consensus.

RNU6-42P by C9orf24 expression — UCEC

Explore this box plot interactively →