C9orf24

Across TCGA pan-cancer cohorts, C9orf24 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated C9orf24 data layer compared with 4 for mutation status.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher C9orf24 RNA is associated with better overall survival. In most high-consensus cancer types, elevated C9orf24 expression acts as an unfavorable survival marker, although some lineages such as CESC and BRCA show a favorable association.

CESC, ESCA, and BRCA are the cancer types where C9orf24 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	OS	Quartile	All	0.904	0.714	.001	32	view →
ESCA	DFS	Tertile	All	0.116	0.757	<.001	27	view →
BRCA	OS	Tertile	All	0.697	0.447	.004	26	view →
UCEC	OS	Quartile	All	0.990	0.915	.003	20	view →
LGG	OS	Quartile	All	0.717	0.867	.001	19	view →
ACC	DFS	Quartile	III,IV	0.468	0.061	.006	17	view →
PAAD	OS	Median	All	0.579	0.389	.005	14	view →
KIRP	DFS	Median	All	0.946	0.870	.006	14	view →
HNSC	DFS	Tertile	IV	0.737	0.557	.006	13	view →
CHOL	DFS	Tertile	II,III,IV	0.146	0.544	.005	12	view →
SKCM	OS	Tertile	IV	1.000	0.188	.005	12	view →
SARC	OS	Tertile	All	0.636	0.344	.015	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

C9orf24–CESC (OS)

Open the CESC breakdown →