C9orf16

Across TCGA patient cohorts, C9orf16 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. COAD shows the largest number of these associations.

The most reproducible C9orf16-associated genes across cancer lineages are RNU6-591P, FAM197Y1, and FAM41AY1. Each is linked with C9orf16 in more than 1 cancer types. Because this analysis shows association rather than direction, both C9orf16-to-partner and partner-to-C9orf16 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-591P grouped by C9orf16-low versus C9orf16-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C9orf16→partner) and Y-score (partner→C9orf16) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RNU6-591P →	+0.373	+7.741	<.001	.009	3	1
COAD	FAM197Y1 →	+0.064	+7.741	<.001	.009	3	1
COAD	FAM41AY1 →	+0.054	+7.741	<.001	.009	3	1
COAD	MIR5689 →	+0.468	+7.741	<.001	.009	3	1
UCEC	RNU6-103P →	+0.502	+5.031	<.001	.009	3	1
UCEC	RNU6-40P →	+0.621	+5.551	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

RNU6-591P by C9orf16 expression — COAD

Explore this box plot interactively →