C9

Across TCGA cell cohorts, C9 mutation is significantly associated with the RNA expression of many other genes, with 354 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible C9-associated genes across cancer lineages are HTD2, SPATA31D1, and TEX28. Each is linked with C9 in more than 1 cancer types. Because this analysis shows association rather than direction, both C9-to-partner and partner-to-C9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HTD2 grouped by C9-low versus C9-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C9→partner) and Y-score (partner→C9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	HTD2 →	+0.539	+3.169	.001	.009	3	2
BREAST	SPATA31D1 →	+0.016	+5.781	<.001	.001	3	2
BREAST	TEX28 →	+0.026	+5.781	<.001	.001	3	2
LARGE_INTESTINE	HSCB →	+0.544	+3.169	.004	.009	3	1
LARGE_INTESTINE	CBY1 →	+0.601	+2.451	.001	.009	3	1
LARGE_INTESTINE	GNPNAT1 →	+0.784	+3.588	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 354 associations by consensus.

HTD2 by C9 expression — LARGE_INTESTINE

Explore this box plot interactively →