C9

Across TCGA pan-cancer cohorts, C9 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of C9’s most consistent transcriptional readouts.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where C9 RNA is repressed in tumor relative to normal tissue. In most cancer types C9 is over-expressed in tumor, although a few such as LIHC and KIRP show the opposite, repressed pattern.

LIHC, KIRP, and KIRC are the cancer types where C9 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in C9 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LIHC	Female	All	−6.154	<.001	9	view →
KIRP	Male	II,III,IV	−0.658	<.001	9	view →
KIRC	Male	All	−0.512	<.001	8	view →
HNSC	All	All	+0.228	<.001	8	view →
CHOL	Female	All	−9.013	<.001	5	view →
LUSC	Female	II,III,IV	+0.407	<.001	5	view →
BLCA	Female	III,IV	+0.282	.032	4	view →
STAD	All	All	+0.190	.008	3	view →
COAD	All	All	+0.054	.005	3	view →
LUAD	All	II,III,IV	+0.103	.027	2	view →
THCA	All	All	−0.042	.008	2	view →
BRCA	All	III,IV	−0.041	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

C9–LIHC

Open the LIHC breakdown →