C8orf44-SGK3

Across TCGA patient cohorts, C8orf44-SGK3 RNA expression is significantly associated with the go_rna of many other GO terms, with 7,052 significant associations in total. KIRC shows the largest number of these associations.

The most reproducible C8orf44-SGK3-associated GO terms across cancer lineages are mRNA alternative polyadenylation, Protein-containing complex disassembly, and Negative regulation of telomere maintenance. Each is linked with C8orf44-SGK3 in more than 31 cancer types. Because this analysis shows association rather than direction, both C8orf44-SGK3-to-partner and partner-to-C8orf44-SGK3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mRNA alternative polyadenylation grouped by C8orf44-SGK3-low versus C8orf44-SGK3-high in UVM.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (C8orf44-SGK3→partner) and Y-score (partner→C8orf44-SGK3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UVM	mRNA alternative polyadenylation →	+0.070	+0.080	<.001	<.001	3	32
STAD	Protein-containing complex disassembly →	+0.045	+0.087	<.001	<.001	3	32
ESCA	Negative regulation of telomere maintenance →	+0.047	+0.100	<.001	<.001	3	31
THYM	Steroid hormone mediated signaling pathway →	+0.046	+0.135	<.001	<.001	3	31
UVM	Positive regulation of mRNA processing →	+0.071	+0.097	<.001	<.001	3	31
ESCA	Golgi organization →	+0.072	+0.173	<.001	<.001	3	31

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,052 associations by consensus.

mRNA alternative polyadenylation by C8orf44-SGK3 expression — UVM

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