C8orf33

Across TCGA patient cohorts, C8orf33 mutation is significantly associated with the RNA expression of many other genes, with 938 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C8orf33-associated genes across cancer lineages are DEFB106B, RNU6-220P, and LATS2-AS1. Each is linked with C8orf33 in more than 1 cancer types. Because this analysis shows association rather than direction, both C8orf33-to-partner and partner-to-C8orf33 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DEFB106B grouped by C8orf33-low versus C8orf33-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C8orf33→partner) and Y-score (partner→C8orf33) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	DEFB106B →	+0.104	+8.471	<.001	.005	3	2
SKCM	RNU6-220P →	+0.380	+4.771	<.001	.006	3	2
SKCM	LATS2-AS1 →	+0.164	+4.296	<.001	.008	3	1
SKCM	MRPL50P1 →	+0.308	+5.328	<.001	.003	3	1
SKCM	DNAJA1P2 →	+0.049	+4.410	.002	.006	3	1
SKCM	OR11Q1P →	+0.822	+5.328	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 938 associations by consensus.

DEFB106B by C8orf33 expression — BRCA

Explore this box plot interactively →