Q-omics provides the consensus-scored DEFB106B profile across patient tissues and cancer cell-line models. DEFB106B expression is associated with patient survival in 7 of 34 cancer types, with the highest sampling consensus in COAD. Additionally, DEFB106B RNA expression shows 4,881 significant pathway-activity associations, with the highest sampling consensus in STAD. Together, these results highlight COAD, and STAD as cancer lineages where DEFB106B shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.

Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.

Premium analyses for DEFB106B — synthetic lethality, tumor antigen, and pembrolizumab response.

View premium →

Survival associations

This table summarizes DEFB106B survival associations across molecular data types. DEFB106B RNA expression shows survival associations in the most cancer types (7), followed by mutation status (1). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.

DEFB106B data type	Survival analysis	Lineage consensus	Lineage of highest sampling consensus
RNA	Kaplan–Meier	7	COAD (144)	view →
Mutation	Kaplan–Meier	1	SKCM (22)	view →

This table ranks reproducible DEFB106B RNA expression–survival associations across cancer types. High DEFB106B expression shows unfavorable associations in COAD, UCEC, BLCA, LUAD, STAD and PRAD. The COAD Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify COAD as the clearest survival context for DEFB106B RNA expression.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	OS	Tertile	All	0.039	0.871	<.001	144	view →
UCEC	DFS	Tertile	All	0.124	0.839	<.001	90	view →
BLCA	DFS	Tertile	All	0.194	0.627	.007	54	view →
LUAD	OS	Tertile	All	0.281	0.812	.007	27	view →
STAD	DFS	Tertile	All	0.289	0.721	.001	21	view →
PRAD	DFS	Tertile	All	0.106	0.886	<.001	18	view →

Pink = unfavorable, green = favorable. all 7 lineages →

DEFB106B-COAD (OS)

Kaplan–Meier survival curve for DEFB106B RNA expression in COAD: high vs low expression groups.

Explore this curve interactively →

Cross-omics associations

This table shows molecular features associated with DEFB106B in patient tissues and cancer cell lines. In patient samples, DEFB106B shows the broadest associations at the RNA and protein expression levels, with STAD recurring as the lineage with the largest associated feature set.

Associated data type	Strength (# associated data)	Lineage of highest associated data
▼RNA
Function (RNA)	4,881	STAD (4806)	view →
RNA	2,724	LUSC (1122)	view →
▼Mutation
RNA	42	UCEC (29)	view →