Across TCGA pan-cancer cohorts, DEFB106B RNA is linked to patient survival in 7 of 34 cancer types, making it the most broadly survival-associated DEFB106B data layer compared with 1 for mutation status.
The strongest signal is observed in colon adenocarcinoma (COAD), where higher DEFB106B RNA is associated with worse overall survival. In most high-consensus cancer types, elevated DEFB106B expression acts as an unfavorable survival marker, although some lineages such as HNSC show a favorable association.
COAD, UCEC, and BLCA are the cancer types where DEFB106B RNA most reproducibly stratifies survival.
RNA survival associations by lineage
Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.