C8B

Across TCGA patient cohorts, C8B mutation is significantly associated with the RNA expression of many other genes, with 3,042 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C8B-associated genes across cancer lineages are REPS1, MIR3922, and PIGW. Each is linked with C8B in more than 3 cancer types. Because this analysis shows association rather than direction, both C8B-to-partner and partner-to-C8B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, REPS1 grouped by C8B-low versus C8B-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C8B→partner) and Y-score (partner→C8B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	REPS1 →	+0.287	+1.305	<.001	<.001	3	4
LGG	MIR3922 →	+0.424	+5.602	<.001	.004	3	3
UCEC	PIGW →	+0.607	+2.654	<.001	<.001	3	3
HNSC	OR6C70 →	+0.614	+3.443	<.001	.007	3	3
COAD	GPR3 →	+0.683	+3.584	<.001	.002	3	3
LUSC	RNU6-1092P →	+0.225	+3.211	.002	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,042 associations by consensus.

REPS1 by C8B expression — SKCM

Explore this box plot interactively →