C8B

Across TCGA patient cohorts, C8B mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C8B-associated genes across cancer lineages are INPP4B, JNK2, and MEK1. Each is linked with C8B in more than 1 cancer types. Because this analysis shows association rather than direction, both C8B-to-partner and partner-to-C8B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, INPP4B grouped by C8B-low versus C8B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C8B→partner) and Y-score (partner→C8B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	INPP4B →	-0.250	-3.459	.025	.005	3	2
UCEC	JNK2 →	+0.243	+1.916	<.001	.009	3	2
UCEC	MEK1 →	+0.317	+2.584	.012	.010	3	2
UCEC	Annexin-1 →	+0.406	+2.604	.026	.005	3	2
UCEC	Caspase-8 →	-0.194	-3.780	.026	<.001	3	2
SKCM	IRS1 →	+0.104	+1.519	.011	.014	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

INPP4B by C8B expression — UCEC

Explore this box plot interactively →