C7orf26

Across TCGA cell cohorts, C7orf26 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,686 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible C7orf26-associated GO terms across cancer lineages are Positive regulation of isotype switching to IgG isotypes, Meiotic attachment of telomere to nuclear envelope, and 2-oxoglutarate decarboxylation to succinyl-CoA. Each is linked with C7orf26 in more than 15 cancer types. Because this analysis shows association rather than direction, both C7orf26-to-partner and partner-to-C7orf26 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of isotype switching to IgG isotypes grouped by C7orf26-low versus C7orf26-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (C7orf26→partner) and Y-score (partner→C7orf26) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Positive regulation of isotype switching to IgG isotypes →	+0.132	+0.958	.002	.001	2	16
BLOOD_Myeloma	Meiotic attachment of telomere to nuclear envelope →	+0.188	+0.862	<.001	<.001	3	14
SKIN	2-oxoglutarate decarboxylation to succinyl-CoA →	+0.154	+1.111	<.001	<.001	3	14
BLOOD_Myeloma	Meiotic telomere tethering at nuclear periphery →	+0.188	+0.862	<.001	<.001	3	14
BLOOD_Myeloma	Meiotic telomere clustering →	+0.188	+0.862	<.001	<.001	3	14
BONE	Positive regulation of gene expression, epigenetic →	+0.086	+1.062	.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,686 associations by consensus.

Positive regulation of isotype switching to IgG isotypes by C7orf26 expression — STOMACH

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