C7orf25

Across TCGA patient cohorts, C7orf25 mutation is significantly associated with the total protein of many other genes, with 40 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C7orf25-associated genes across cancer lineages are MEK1, 14-3-3_beta, and A-Raf_pS299. Each is linked with C7orf25 in more than 1 cancer types. Because this analysis shows association rather than direction, both C7orf25-to-partner and partner-to-C7orf25 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by C7orf25-low versus C7orf25-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C7orf25→partner) and Y-score (partner→C7orf25) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.375	+2.502	.002	.001	3	2
UCEC	14-3-3_beta →	-0.108	-2.780	.001	.003	3	1
UCEC	A-Raf_pS299 →	-0.102	-1.584	.012	.034	3	1
UCEC	ERK2 →	+0.139	+1.247	.034	.045	3	1
UCEC	FoxM1 →	+0.182	+1.807	.038	.004	3	1
UCEC	GATA6 →	-0.125	-1.355	.021	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

MEK1 by C7orf25 expression — UCEC

Explore this box plot interactively →