C7orf25

Across TCGA pan-cancer cohorts, C7orf25 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of C7orf25’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where C7orf25 RNA is repressed in tumor relative to normal tissue. In most cancer types C7orf25 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

THCA, HNSC, and KICH are the cancer types where C7orf25 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in C7orf25 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	II,III,IV	−0.296	<.001	10	view →
HNSC	Male	II,III,IV	+0.215	<.001	10	view →
KICH	Female	All	−0.389	<.001	8	view →
BLCA	All	All	+0.348	<.001	8	view →
LIHC	Male	All	+0.299	<.001	8	view →
STAD	All	II,III,IV	+0.230	.002	5	view →
LUSC	All	All	+0.215	<.001	5	view →
COAD	All	All	+0.134	.003	5	view →
CHOL	Male	All	+0.378	<.001	4	view →
BRCA	All	II,III,IV	+0.096	.022	4	view →
ESCA	All	II,III,IV	+0.470	.038	2	view →
PAAD	All	All	+0.262	.006	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

C7orf25–THCA

Open the THCA breakdown →