C7orf25

Across TCGA pan-cancer cohorts, C7orf25 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated C7orf25 data layer compared with 5 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in kidney chromophobe (KICH), where higher C7orf25 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated C7orf25 expression acts as an unfavorable survival marker, although some lineages such as LUSC and BRCA show a favorable association.

KICH, LUSC, and UVM are the cancer types where C7orf25 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KICH	OS	Median	All	0.720	1.000	<.001	80	view →
LUSC	OS	Median	All	0.830	0.719	<.001	40	view →
UVM	DFS	Tertile	III,IV	0.225	0.854	.001	31	view →
MESO	DFS	Median	II,III,IV	0.206	0.339	.020	30	view →
GBM	OS	Tertile	All	0.191	0.329	.002	21	view →
BRCA	DFS	Tertile	II,III,IV	0.915	0.857	.017	20	view →
ACC	OS	Tertile	IV	0.857	0.287	.001	19	view →
LUAD	DFS	Median	IV	0.501	0.862	.006	18	view →
STAD	DFS	Tertile	IV	0.137	0.670	.004	18	view →
LGG	OS	Quartile	All	0.826	0.931	.001	14	view →
HNSC	DFS	Median	All	0.556	0.691	.002	14	view →
SCLC	DFS	Tertile	IV	0.155	0.758	.022	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

C7orf25–KICH (OS)

Open the KICH breakdown →