C6orf52

Across TCGA cell cohorts, C6orf52 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. OESOPHAGUS shows the largest number of these associations.

The most reproducible C6orf52-associated genes across cancer lineages are MBD3L3, MBD3L4, and PFN3. Each is linked with C6orf52 in more than 1 cancer types. Because this analysis shows association rather than direction, both C6orf52-to-partner and partner-to-C6orf52 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MBD3L3 grouped by C6orf52-low versus C6orf52-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C6orf52→partner) and Y-score (partner→C6orf52) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	MBD3L3 →	+0.020	+4.906	<.001	.006	3	1
OESOPHAGUS	MBD3L4 →	+0.020	+4.906	<.001	.006	3	1
LARGE_INTESTINE	PFN3 →	+0.169	+4.467	<.001	.004	3	1
LARGE_INTESTINE	IQCF6 →	+0.311	+4.467	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

MBD3L3 by C6orf52 expression — OESOPHAGUS

Explore this box plot interactively →