C6orf52

Across TCGA pan-cancer cohorts, C6orf52 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated C6orf52 data layer compared with 1 for mutation status and 2 for mass-spec protein.

The strongest signal is observed in small cell lung cancer (SCLC), where higher C6orf52 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated C6orf52 expression acts as an unfavorable survival marker, although some lineages such as SCLC and LUSC show a favorable association.

SCLC, ACC, and KICH are the cancer types where C6orf52 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SCLC	DFS	Median	II,III,IV	0.541	0.150	<.001	55	view →
ACC	DFS	Tertile	All	0.194	0.659	<.001	51	view →
KICH	OS	Tertile	III,IV	0.242	0.837	.002	50	view →
MESO	OS	Median	All	0.428	0.655	<.001	48	view →
LIHC	DFS	Tertile	All	0.445	0.628	<.001	48	view →
SARC	OS	Quartile	All	0.330	0.763	.002	30	view →
LUSC	DFS	Quartile	II,III,IV	0.788	0.414	.007	29	view →
THCA	OS	Median	All	0.963	1.000	.011	27	view →
BRCA	DFS	Tertile	III,IV	0.792	0.910	.008	26	view →
UCEC	OS	Median	All	0.774	0.578	.001	26	view →
LGG	OS	Median	All	0.927	0.860	.002	20	view →
DLBC	DFS	Median	II,III,IV	0.971	0.541	.011	17	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

C6orf52–SCLC (DFS)

Open the SCLC breakdown →