C5orf63

Across TCGA patient cohorts, C5orf63 mutation is significantly associated with the RNA expression of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C5orf63-associated genes across cancer lineages are ALX3, OTOP1, and FSHR. Each is linked with C5orf63 in more than 1 cancer types. Because this analysis shows association rather than direction, both C5orf63-to-partner and partner-to-C5orf63 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ALX3 grouped by C5orf63-low versus C5orf63-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C5orf63→partner) and Y-score (partner→C5orf63) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ALX3 →	+0.848	+3.785	<.001	.003	3	1
UCEC	OTOP1 →	+0.491	+3.547	.004	.007	3	1
UCEC	FSHR →	+0.088	+3.452	.005	.003	3	1
UCEC	IGKV2OR2-2 →	+0.159	+3.344	.005	.008	3	1
UCEC	MIR6864 →	+1.072	+3.061	<.001	.008	3	1
UCEC	RN7SL478P →	+0.467	+3.676	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

ALX3 by C5orf63 expression — UCEC

Explore this box plot interactively →