C5orf63

Across TCGA pan-cancer cohorts, C5orf63 RNA is linked to patient survival in 28 of 34 cancer types, making it the most broadly survival-associated C5orf63 data layer.

The strongest signal is observed in mesothelioma (MESO), where higher C5orf63 RNA is associated with better overall survival. In most high-consensus cancer types, elevated C5orf63 expression acts as an unfavorable survival marker, although some lineages such as MESO and KIRP show a favorable association.

MESO, KICH, and OV are the cancer types where C5orf63 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Tertile	III,IV	0.652	0.346	<.001	82	view →
KICH	DFS	Median	II,III,IV	0.677	1.000	.001	72	view →
OV	DFS	Tertile	II,III,IV	0.473	0.595	.005	60	view →
LGG	OS	Median	All	0.731	0.888	<.001	54	view →
CESC	DFS	Median	All	0.440	0.640	<.001	42	view →
STAD	DFS	Median	III,IV	0.380	0.597	.003	32	view →
KIRP	DFS	Quartile	All	1.000	0.565	.004	32	view →
LIHC	OS	Median	All	0.713	0.833	.001	26	view →
PAAD	DFS	Quartile	All	0.401	0.163	.009	25	view →
UCS	DFS	Tertile	IV	0.936	0.323	.024	24	view →
SCLC	DFS	Tertile	II,III,IV	0.176	0.580	.010	21	view →
ACC	DFS	Tertile	III,IV	0.709	0.281	.006	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 28 lineages.

C5orf63–MESO (OS)

Open the MESO breakdown →